A　series　of　novel　8-azapurine　carbocyclic　nucleoside　hydrazones　were　synthesized　through　a　useful　procedure　starting　from　amino　alcohol　and　pyrimido　dichloride.　All　the　products　were　characterized　by　H-1　NMR,　C-13　NMR　and　HRMS　spectral　analysis　and　the　stereochemical　structure　of　key　intermediate　was　also　confirmed　by　a　single　crystal　X-ray　diffraction　crystallographic　analysis.　Moreover,　the　anticancer　activities　were　evaluated　in　vitro　against　human　liver　cancer　Huh-7　cell　line　and　human　breast　cancer　A549　cell　line.　(C)　2015　Published　by　Elsevier　Ltd.