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作者:

Ren, H. X. (Ren, H. X..) | Liu, Sh. Q. (Liu, Sh. Q..) | Zhang, X. C. (Zhang, X. C..) | Zeng, Y. J. (Zeng, Y. J..)

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Scopus SCIE

摘要:

Spike timing-dependent plasticity (STDP) plays an important role in sculpting information-storing circuits in the hippocampus, since motor learning and memory are thought to be closely linked with this classical plasticity. To further understand the information delivery in a hippocampus circuit, we build a computational model to study the potential role of linear changes in the synaptic weight and synaptic number. Several key results have been obtained: (i) Changes in the synaptic weight and numbers lead to different long-term modifications; (ii) the first paired spiking from two neurons significantly influences the adjusted subsequent paired spiking; the pre-post spiking pair strengthens the following paired spiking; however, the post-pre spiking pair depresses the subsequent spiking; (iii) when the synaptic weight and synaptic numbers are changed, the interval of the first spiking pair may undergo reduction, and (iv) when we stimulate a stellate neuron weakly or decrease the capacitance of the CA1 pyramidal neuron, LTP is more easily produced than LTD; on the contrary, LTD is more easily produced in an opposite situation; increase in the synaptic numbers can promote activation of the CA1 pyramidal neuron.

关键词:

computational model hippocampus neuronal circuits spike timing-dependent synaptic plasticity (STDP) synaptic weight and number

作者机构:

  • [ 1 ] [Ren, H. X.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China
  • [ 2 ] [Liu, Sh. Q.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China
  • [ 3 ] [Zhang, X. C.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China
  • [ 4 ] [Zeng, Y. J.]Beijing Univ Technol, Ctr Biomed Engn, Beijing, Peoples R China

通讯作者信息:

  • [Liu, Sh. Q.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China

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来源 :

NEUROPHYSIOLOGY

ISSN: 0090-2977

年份: 2015

期: 4

卷: 47

页码: 264-270

0 . 5 0 0

JCR@2022

ESI学科: NEUROSCIENCE & BEHAVIOR;

ESI高被引阀值:166

JCR分区:4

中科院分区:4

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WoS核心集被引频次: 0

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ESI高被引论文在榜: 0 展开所有

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