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Author:

Wang, Jing (Wang, Jing.) | Liu, Shenquan (Liu, Shenquan.) | Liu, Xuanliang (Liu, Xuanliang.) | Zeng, Yanjun (Zeng, Yanjun.)

Indexed by:

EI Scopus SCIE

Abstract:

Using a model of individual isolated pancreatic beta-cells, we investigated bifurcation diagrams of interspike intervals (ISIs) and largest Lyapunov exponents (LLE), which clearly demonstrated a wide range of transitions between different firing patterns. The numerical simulation results revealed the effect of different time constants and ion channels on the neuronal discharge rhythm. Furthermore, an individual cell exhibited tonic spiking, square-wave bursting, and tapered bursting. Additionally, several bifurcation phenomena can be observed in this paper, such as period-doubling, period-adding, inverse period-doubling and inverse period-adding scenarios. In addition, we researched the mechanisms underlying two kinds of bursting (tapered and square-wave bursting) by use of fast-slow dynamics analysis. Finally, we analyzed the codimension-two bifurcation of the fast subsystem and studied cusp bifurcation, generalized Hopf (or Bautin) bifurcation and Bogdanov-Takens bifurcation.

Keyword:

largest Lyapunov exponents (LLE) Bifurcation pancreatic beta-cell fast-slow dynamics analysis interspike intervals (ISIs) firing patterns

Author Community:

  • [ 1 ] [Wang, Jing]S China Univ Technol, Sch Math, Guangzhou 510640, Peoples R China
  • [ 2 ] [Liu, Shenquan]S China Univ Technol, Sch Math, Guangzhou 510640, Peoples R China
  • [ 3 ] [Liu, Xuanliang]S China Univ Technol, Sch Math, Guangzhou 510640, Peoples R China
  • [ 4 ] [Zeng, Yanjun]Beijing Univ Technol, Ctr Biomed Engn, Beijing 100022, Peoples R China

Reprint Author's Address:

  • [Liu, Shenquan]S China Univ Technol, Sch Math, Guangzhou 510640, Peoples R China

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Source :

INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS

ISSN: 0218-1274

Year: 2015

Issue: 9

Volume: 25

2 . 2 0 0

JCR@2022

ESI Discipline: MATHEMATICS;

ESI HC Threshold:82

JCR Journal Grade:2

CAS Journal Grade:3

Cited Count:

WoS CC Cited Count: 11

SCOPUS Cited Count: 12

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 1

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