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作者:

Wang, Jing (Wang, Jing.) | Liu, Shenquan (Liu, Shenquan.) | Liu, Xuanliang (Liu, Xuanliang.) | Zeng, Yanjun (Zeng, Yanjun.)

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EI Scopus SCIE

摘要:

Using a model of individual isolated pancreatic beta-cells, we investigated bifurcation diagrams of interspike intervals (ISIs) and largest Lyapunov exponents (LLE), which clearly demonstrated a wide range of transitions between different firing patterns. The numerical simulation results revealed the effect of different time constants and ion channels on the neuronal discharge rhythm. Furthermore, an individual cell exhibited tonic spiking, square-wave bursting, and tapered bursting. Additionally, several bifurcation phenomena can be observed in this paper, such as period-doubling, period-adding, inverse period-doubling and inverse period-adding scenarios. In addition, we researched the mechanisms underlying two kinds of bursting (tapered and square-wave bursting) by use of fast-slow dynamics analysis. Finally, we analyzed the codimension-two bifurcation of the fast subsystem and studied cusp bifurcation, generalized Hopf (or Bautin) bifurcation and Bogdanov-Takens bifurcation.

关键词:

Bifurcation fast-slow dynamics analysis firing patterns interspike intervals (ISIs) largest Lyapunov exponents (LLE) pancreatic beta-cell

作者机构:

  • [ 1 ] [Wang, Jing]S China Univ Technol, Sch Math, Guangzhou 510640, Peoples R China
  • [ 2 ] [Liu, Shenquan]S China Univ Technol, Sch Math, Guangzhou 510640, Peoples R China
  • [ 3 ] [Liu, Xuanliang]S China Univ Technol, Sch Math, Guangzhou 510640, Peoples R China
  • [ 4 ] [Zeng, Yanjun]Beijing Univ Technol, Ctr Biomed Engn, Beijing 100022, Peoples R China

通讯作者信息:

  • [Liu, Shenquan]S China Univ Technol, Sch Math, Guangzhou 510640, Peoples R China

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来源 :

INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS

ISSN: 0218-1274

年份: 2015

期: 9

卷: 25

2 . 2 0 0

JCR@2022

ESI学科: MATHEMATICS;

ESI高被引阀值:54

JCR分区:2

中科院分区:3

被引次数:

WoS核心集被引频次: 11

SCOPUS被引频次: 12

ESI高被引论文在榜: 0 展开所有

万方被引频次:

中文被引频次:

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