A　series　of　potential　HIV-1　integrase　inhibitors　based　on　5-chloro-2-hydroxy-3-triazolylbenzoic　acid　scaffold　was　designed　and　synthesized.　Some　of　these　compounds　exhibit　potent　inhibitory　activities　at　micromolar　concentrations　against　HIV-1　integrase　in　the　3＇-end　processing　and　the　strand　transfer　step.