Existing　research　on　progressive　collapse　of　building　structures　mainly　focuses　on　concrete　and　steel　frame　structures.　To　investigate　the　progressive　collapse　resistance　of　high-rise　RC　frame　shear　wall　structures,　two　typical　15-story　building　models　are　designed　with　equivalent　overall　lateral　resistance　to　seismic　actions.　However,　the　structural　layouts　in　resisting　the　lateral　forces　are　quite　different　for　the　two　buildings.　Building　A　is　a　weak　wall-strong　frame　structure,　whereas　building　B　is　a　strong　wall-weak　frame　system.　Three-dimensional　(3D)　finite-element　models　of　the　two　structures　are　established　using　fiber　beam　and　multilayer　shell　elements.　The　progressive　collapse　resistances　of　the　frames　and　the　shear　walls　in　both　structures　are　evaluated　under　various　column　(shear　wall)　removal　scenarios.　Results　demonstrate　that　there　is　a　difference　in　progressive　collapse　prevention　performance　for　different　structural　layouts.　The　progressive　collapse　resistance　tends　to　be　inadequate　for　the　strong　wall-weak　frame　system.　Such　a　system　is　subsequently　redesigned　using　the　linear　static　alternate　path　(AP)　method　proposed　in　GSA　guideline,　through　which　the　reliability　and　efficiency　of　the　method　are　confirmed.　The　outcome　of　this　study　has　provided　a　reference　for　progressive　collapse　prevention　designs　of　typical　and　representative　high-rise　RC　frame　shear　wall　structures.