Differential expression profiling of microRNAs in para-carcinoma, carcinoma and relapse human pancreatic cancer - 文章详情页

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Scopus SCIE

摘要：

To　explore　the　altered　different　expression　of　miRNAs　and　the　mechanisms　underlying　the　relapse　and　metastasis　of　pancreatic　cancer.　The　most　differentially　expressed　miRNAs　were　analyzed　by　gene　ontology　(GO)　term　analysis,　Kyoto　encyclopedia　of　genes　and　genomes　(KEGG)　pathway　analysis　and　protein　interaction　analysis.　The　potentially　regulated　target　genes　of　the　most　differentially　expressed　miRNAs　were　also　analyzed　further　by　GO　term　analysis　and　KEGG　pathway　analysis,　and　quantitated　by　qRT-PCR.　In　total,　we　found　12　miRNAs　displayed　at　least　a　30-fold　increase　or　decrease　in　expression　of　carcinoma　and　relapse　vs.　para-carcinoma　human　pancreatic　cancer　(C/R　vs.　P).　In　addition,　our　study　found　that　pancreatic　cancer　was　related　to　pathways　in　cancer,　including　Jak-STAT　signaling　pathway,　MAPK　signaling　pathway　and　PPAR　signaling　pathway.　The　differential　expressed　miRNAs　and　their　predicted　target　genes　that　involved　in　Jak-STAT　signaling　pathway,　MAPK　signaling　pathway　and　PPAR　signaling　pathway　indicating　their　potential　roles　in　pancreatic　carcinogenesis　and　progress.

关键词：

miRNA Metastasis Pancreatic cancer Microarray Relapse

作者机构：

[ 1 ] [Lai, X. -L.]Hunan Agr Univ, Fac Vet, Coll Vet Med, Changsha 410128, Hunan, Peoples R China
[ 2 ] [Chang, Z. -Y.]Hunan Agr Univ, Fac Vet, Coll Vet Med, Changsha 410128, Hunan, Peoples R China
[ 3 ] [Fu, D.]Hunan Agr Univ, Fac Vet, Coll Vet Med, Changsha 410128, Hunan, Peoples R China
[ 4 ] [Li, W. -P.]Hunan Agr Univ, Fac Vet, Coll Vet Med, Changsha 410128, Hunan, Peoples R China
[ 5 ] [Huang, Y. -H.]China Japan Union Hosp, Ctr Sci Res, Changchun 130033, Peoples R China
[ 6 ] [Wang, L. -P.]China Japan Union Hosp, Ctr Sci Res, Changchun 130033, Peoples R China
[ 7 ] [Sun, R.]China Japan Union Hosp, Ctr Sci Res, Changchun 130033, Peoples R China
[ 8 ] [Cong, X. -L.]China Japan Union Hosp, Ctr Sci Res, Changchun 130033, Peoples R China
[ 9 ] [Huang, Y. -H.]Beijing Univ Technol, Coll Sci Bioengn, Beijing 100124, Peoples R China
[ 10 ] [Li, Y. -S.]Cent S Univ, Dept Orthoped, Xiangya Hosp, Changsha 410128, Hunan, Peoples R China
[ 11 ] [Li, Y. -S.]Adm Bur Petr North China, Gen Hosp, Dept Gen Surg, Renqiu 062552, Peoples R China
[ 12 ] [Han, X.]Adm Bur Petr North China, Gen Hosp, Dept Gen Surg, Renqiu 062552, Peoples R China
[ 13 ] [Li, G. -N.]Beihua Univ, Fac Med, Fengman 132013, Jilin, Peoples R China
[ 14 ] [Ma, Y. -S.]Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Nucl Med, Shanghai 200072, Peoples R China
[ 15 ] [Feng, S. -Y.]Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Nucl Med, Shanghai 200072, Peoples R China
[ 16 ] [Fu, D.]Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Nucl Med, Shanghai 200072, Peoples R China
[ 17 ] [Wang, X. -H.]Adm Bur Petr North China, Gen Hosp, Dept Endoscorp Inventiona, Renqiu 062552, Peoples R China

通讯作者信息：

[Li, W. -P.]Hunan Agr Univ, Fac Vet, Coll Vet Med, Changsha 410128, Hunan, Peoples R China

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dongchen0001@126.com |
sunxing021@126.com

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