We　report　for　the　first　time　seeing　and　counting　integrin　a(IIb)beta(3)　on　a　single-cell　level.　The　proposed　method　is　based　on　the　using　of　the　Au　cluster　probe.　With　the　fluorescent　property　of　Au-24　cluster　and　the　specific　targeting　ability　of　peptide,　our　probe　can　directly　visualize　integrin　a(IIb)beta(3)　on　the　membrane　of　human　erythroleukemia　cells　(HEL)　via　confocal　microscopy.　On　the　basis　of　the　accurate　formula　of　our　probe　(Au(24)Peptide(8)),　the　number　of　integrin　a(IIb)beta(3)　can　be　precisely　counted　by　quantifying　the　gold　content　on　a　single　HEL　cell　via　laser　ablation　inductively　coupled　plasma　mass　spectrometry.　Our　results　reveal　that　the　number　of　integrin　a(IIb)beta(3)　on　a　single　cell　varies　from　5.75　x　10(-17)　to　9.11　x　10(-17)　mol,　because　of　the　heteroexpression　levels　of　a(IIb)beta(3)　on　individual　cells.