The　isolation　seismic　technology　has　been　developed　during　the　past　three　decades,　but　it　is　a　current　focus　in　bridge　seismic　research　and　practice.　In　order　to　investigate　the　nonlinear　seismic　responses　of　isolated　bridges　and　evaluate　the　effects　of　seismic　isolation　on　the　peak　response　of　the　bridges　with　lead　rubber　bearings　(LRB)　under　bi-directional　horizontal　earthquake　excitation,　an　analytical　method　of　nonlinear　seismic　responses　of　continuous　multi-span　girder　bridges　with　LRB　and　its　solving　method　are　presented　considering　the　interaction　between　the　restoring　forces　of　the　bearings.　Shaking　table　test　of　1/10　the　scaled　model　of　two-span　girder　isolated　bridge　with　LRB　have　been　conducted　to　verify　effectiveness　of　the　LRB　as　a　seismic　isolation　device　and　peak　response　of　isolated　bridges.　Experimental　results　well　agreed　with　the　results　obtained　from　analytical　results　of　peak　displacement　and　acceleration　of　deck,　displacement　and　force-displacement　hysteresis　loops　of　isolators.　It　is　verified　that　analytical　method　given　this　paper　is　right　and　effective　when　analyzing　nonlinear　earthquake　response　of　continuous　girder　isolated　bridges　with　LRB.　Moreover,　the　bi-directional　coupled　interaction　of　the　restoring　forces　of　LRB　should　be　taken　into　account,　which　has　considerable　effects　on　the　peak　seismic　responses　of　the　isolated　bridge.