Gas　bubbles　induced　during　the　radiofrequency　ablation　(RFA)　of　tissues　can　affect　the　detection　of　ablation　zones　(necrosis　zone　or　thermal　lesion)　during　ultrasound　elastography.　To　resolve　this　problem,　our　previous　study　proposed　ultrasound　Nakagami　imaging　for　detecting　thermal-induced　bubble　formation　to　evaluate　ablation　zones.　To　prepare　for　future　applications,　this　study　(i)　created　a　novel　algorithmic　scheme　based　on　the　frequency　and　temporal　compounding　of　Nakagami　imaging　for　enhanced　ablation　zone　visualization,　(ii)　integrated　the　proposed　algorithm　into　a　clinical　scanner　to　develop　a　real-time　Nakagami　imaging　system　for　monitoring　RFA,　and　(iii)　investigated　the　applicability　of　Nakagami　imaging　to　various　types　of　tissues.　The　performance　of　the　real-time　Nakagami　imaging　system　in　visualizing　RFA-induced　ablation　zones　was　validated　by　measuring　porcine　liver　(n　=　18)　and　muscle　tissues　(n　=　6).　The　experimental　results　showed　that　the　proposed　algorithm　can　operate　on　a　standard　clinical　ultrasound　scanner　to　monitor　RFA　in　real　time.　The　Nakagami　imaging　system　effectively　monitors　RFA-induced　ablation　zones　in　liver　tissues.　However,　because　tissue　properties　differ,　the　system　cannot　visualize　ablation　zones　in　muscle　fibers.　In　the　future,　real-time　Nakagami　imaging　should　be　focused　on　the　RFA　of　the　liver　and　is　suggested　as　an　alternative　monitoring　tool　when　advanced　elastography　is　unavailable　or　substantial　bubbles　exist　in　the　ablation　zone.