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作者:

Zhao, Xi (Zhao, Xi.) | Liu, Youjun (Liu, Youjun.) (学者:刘有军) | Ding, Jinli (Ding, Jinli.) | Ren, Xiaochen (Ren, Xiaochen.) | Bai, Fan (Bai, Fan.) | Zhang, Mingzi (Zhang, Mingzi.) | Ma, Liancai (Ma, Liancai.) | Wang, Wenxin (Wang, Wenxin.) | Xie, Jinsheng (Xie, Jinsheng.) | Qiao, Aike (Qiao, Aike.) (学者:乔爱科)

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摘要:

The modified Blalock-Taussig (BT) shunt is a palliative surgery which can help the tetralogy of Fallot (TOF) patient increase the blood oxygen saturation by interposing a systemic-to-pulmonary artery shunt. Two typical anastomotic shapes are frequently used in clinical practice: the end-to-side (ETS) and the side-to-side (STS) anastomosis. This paper examines the hemodynamic influence of the anastomotic shape in the modified BT shunt. Three models with different anastomotic shapes were reconstructed. The ETS anastomoses were applied in the first model. For the innominate artery (IA) and the pulmonary artery (PA) in the second model, the ETS and the STS anastomosis were applied, respectively. Finally, the STS anastomoses were applied in the third model. The 0D/3D coupling method was used to perform a numerical simulation by coupling the three-dimensional (3D) artery model with a zero-dimensional (0D) lumped parameter model for the cardiovascular system. The simulation results showed that the perfusion into the left and right PA in Model 1 was unbalanced. Swirling flow appeared in the shunt in Model 3, but the shunt flow rate in Model 3 was lower. The ETS anastomosis at the PA may cause unbalanced blood perfusion into the left and right PA. Conversely, the STS anastomosis can make the blood perfusion more balanced. Otherwise,the STS anastomosis at the IA could generate a swirling flow in the shunt which may provide a better hemodynamic environment while decreasing the pulmonary perfusion.

关键词:

0D/3D coupling simulation anastomotic shape computational fluid dynamics (CFD) hemodynamics modified BT shunts

作者机构:

  • [ 1 ] [Zhao, Xi]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 2 ] [Liu, Youjun]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 3 ] [Ren, Xiaochen]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 4 ] [Bai, Fan]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 5 ] [Ma, Liancai]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 6 ] [Wang, Wenxin]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 7 ] [Qiao, Aike]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 8 ] [Ding, Jinli]Capital Med Univ, Dept Diagnost Radiol, Beijing You An Hosp, Beijing 100069, Peoples R China
  • [ 9 ] [Zhang, Mingzi]Tohoku Univ, Inst Fluid Sci, Grad Sch Engn, Ohta Lab,Aoba Ku, Sendai, Miyagi 9808577, Japan
  • [ 10 ] [Xie, Jinsheng]Capital Med Univ, Beijing An Zhen Hosp, Beijing 100029, Peoples R China

通讯作者信息:

  • 刘有军

    [Liu, Youjun]Beijing Univ Technol, Coll Life Sci & Bioengn, 100 Pingleyuan, Beijing 100124, Peoples R China

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来源 :

JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY

ISSN: 0219-5194

年份: 2015

期: 1

卷: 15

0 . 8 0 0

JCR@2022

ESI学科: MOLECULAR BIOLOGY & GENETICS;

ESI高被引阀值:269

JCR分区:4

中科院分区:4

被引次数:

WoS核心集被引频次: 18

SCOPUS被引频次: 18

ESI高被引论文在榜: 0 展开所有

万方被引频次:

中文被引频次:

近30日浏览量: 4

在线人数/总访问数:1993/2919841
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