The　electrochemiluminescence　of　bis(2,　2　＇-bipyridine)　(dipyrido[3,　2-a:2　＇　3　＇-c]phenazine-N4N5)　ruthenium(II)　([Ru(bpy)(2)(dppz)](2+))　was　used　to　monitor　deoxyribonucleic　acid　(DNA)　charge　transfer　with　tri-n-propylamine　as　a　coreactant.　This　system　was　used　to　measure　damage　to　DNA　induced　by　perfluorooctanoic　acid.　Fifteen-base　pairs　of　double-stranded　DNA　with　a　thiol　group　at　the　5　＇　end　position　were　covalently　bonded　to　a　gold　electrode.　An　electrochemiluminescence　sensor　was　then　constructed　by　incubating　the　modified　gold　electrode　in　[Ru(bpy)(2)(dppz)](2+)　solution　for　30min.　For　comparison,　single-stranded　DNA,　well-matched　double-stranded　DNA,　and　single　base-mismatched　double-stranded　DNA　were　assembled　on　the　gold　surface.　The　results　showed　that　the　electrochemiluminescence　behavior　of　the　DNA　sensors　were　unique.　The　electrochemiluminescence　decreased　when　the　[Ru(bpy)(2)(dppz)](2+)-DNA　ECL　sensor　was　incubated　in　a　perfluorooctanoic　acid　solution.　The　damage　to　DNA　caused　by　perfluorooctanoic　acid　was　monitored　using　a　combination　of　DNA　charge　transfer　theory　and　the　interaction　between　DNA　and　[Ru(bpy)(2)(dppz)](2+).　The　detection　limit　for　perfluorooctanoic　acid　was　1x10(-12)mol/L.　[Ru(bpy)(2)(dppz)](2+)　was　shown　to　be　a　sensitive　electrochemiluminescence　sensor　for　the　determination　of　DNA　damage.