This　work　provides　an　improved　new　electroless　galvanic　deposition　method　to　fabricate　and　assemble　silver　nano-dendritic　crystals　(SNDC)　to　be　a　uniform　and　flat　film　on　most　desired　solid　surfaces.　This　SNDC　film　is　shown　to　be　suitable　as　a　new　rapid　dehydration　surface　enhanced　Raman　scattering　(SERS)　substrate,　which　overcomes　the　severely　limited　scope　of　existing　SERS　techniques　in　practical　applications　for　solution　detection.　Scanning　electron　microscopy　(SEM)　characterization　confirms　that　the　SNDC　film　is　composed　of　many　layers　of　SNDCs　in　a　stacked　microcosmic　structure.　This　structure　provides　the　SNDC　film　with　a　large　number　of　internal　interspaces,　and　thus　liquid　can　rapidly　infiltrate　into　the　SNDC　film.　The　result　of　SERS　mapping　shows　that　a　significant　number　of　probe　molecules　are　filtered　out　onto　the　silver　SNDCs　on　the　film　surface.　These　characteristics　indicate　that　the　SNDC　film　can　function　as　a　molecular　filter,　which　can　conveniently　separate　probe　molecules　from　the　test　specimen.　The　SERS　spectra　and　mapping　results　have　demonstrated　a　significant　SERS　enhancement　and　the　excellent　reproducibility　of　SNDCs,　and　are　in　close　agreement　with　finite　different　time　domain　(FDTD)　simulation.　The　combined　effects　of　rapid　water　permeability,　effective　molecular　filterability,　dramatic　SERS　sensitivity　improvement　as　well　as　reproducibility　allow　convenient,　real-time　SERS　applications.