In　this　investigation,　we　have　designed　and　synthesized　a　novel　core-shell　polymer　nanoparticle　system　for　highly　effective　chemo-photothermal　combination　therapy.　A　nanoscale　DSPE-PEG　micelle　encapsulating　doxorubicin　(Dox-M)　was　designed　as　a　core,　and　then　modified　by　a　polydopamine　(PDA)　shell　for　photothermal　therapy　and　bortezomib　(Btz)　administration　(Dox-M@PDA-Btz).　The　facile　conjugation　of　Btz　to　the　catechol-containing　PDA　shell　can　form　a　reversible　pH-sensitive　boronic　acid-catechol　conjugate　to　create　a　stimuli-responsive　drug　carrier　system.　As　expected,　the　micelle@PDA　core-shell　nanoparticles　exhibited　satisfactory　photothermal　efficiency,　which　has　potential　for　thermal　ablation　of　malignant　tissues.　In　addition,　on　account　of　the　PDA　modification,　both　Dox　and　Btz　release　processes　were　pH-dependent　and　NIR-dependent.　Both　in　vitro　and　in　vivo　studies　illustrated　that　the　Dox-M@PDA-Btz　nanoparticles　coupled　with　laser　irradiation　could　enhance　the　cytotoxicity,　and　thus　combinational　therapy　efficacy　was　achieved　when　integrating　Dox,　Btz,　and　PDA　into　a　single　nanoplatform.　Altogether,　our　current　study　indicated　that　the　micelle@polydopamine　core-shell　nanoparticles　could　be　applied　for　NIR/pH-responsive　sustained-release　and　synergized　chemo-photothermal　therapy　for　breast　cancer.