Poor　electrocatalytic　activity　and　carbon　monoxide　(CO)　poisoning　of　the　anode　in　Pt-based　catalysts　are　still　two　major　challenges　facing　direct　methanol　fuel　cells.　Herein,　we　demonstrate　a　highly　active　and　stable　Pt　nanoparticle/Mo2C　nanotube　catalyst　for　methanol　electro-oxidation.　Pt　nanoparticles　were　deposited　on　Mo2C　nanotubes　using　a　controllable　atomic　layer　deposition　(ALD)　technique.　This　catalyst　showed　much　higher　catalytic　activity　for　methanol　oxidation　and　superior　CO　tolerance,　when　compared　with　those　of　the　conventional　Pt/C　and　PtRu/C　catalysts.　The　experimental　evidence　from　X-ray　absorption　near-edge　structure　spectroscopy　and　scanning　transmission　X-ray　microscopy　clearly　support　a　strong　chemical　interaction　between　the　Pt　nanoparticles　and　Mo2C　nanotubes.　Our　studies　show　that　the　existence　of　Mo2C　not　only　minimizes　the　required　Pt　usage　but　also　significantly　enhances　CO　tolerance　and　thus　improves　their　durability.　These　results　provide　a　promising　strategy　for　the　design　of　highly　active　next-generation　catalysts.