In　this　paper,　the　numerical　simulations　have　been　carried　out　to　evaluate　the　two-phase　pressure　drop　and　liquid　distribution　in　screw　channel.　The　numerical　models　are　validated　against　the　present　experimental　data　with　statistical　accuracy.　The　effects　of　pitch　circle　diameter　(PCD),　inlet　velocity　and　inlet　sectional　liquid　holdup　on　the　pressure　drop　and　liquid　distribution　characteristics　in　the　screw　channel　are　illustrated.　It　is　found　that　decreasing　the　PCD　and　increasing　the　inlet　sectional　liquid　holdup　can　increase　the　liquid　holdup　on　the　outer　side　in　screw　channel.　The　PCD　and　the　inlet　sectional　liquid　holdup　need　to　be　considered　in　evaluating　the　two-phase　frictional　pressure　drop　per　unit　length　in　the　screw　channel.　The　PCD　has　an　effect　on　the　development　of　the　average　pressure　in　the　various　cross　sections,　and　the　inlet　sectional　liquid　holdup　has　no　visible　impact　on　the　changing　process　of　the　pressure　drop　in　the　screw　channel.　The　correlation　developed　predicts　the　two-phase　frictional　pressure　drop　in　the　screw　channel　with　great　statistical　accuracy.