The　electrochemical　oxidation　of　chalcone　oximes　has　been　explored　using　preparative　scale　electrolysis　and　cyclic　voltammetry　(CV).　The　results　show　that　a　constant　current　electrolysis　of　chalcone　oximes　in　an　undivided　cell　affords　the　corresponding　isoxazoles　in　moderate　to　good　yields,　using　graphite　as　the　working　electrode　and　NaClO4/CH3OH　as　the　supporting　electrolyte.　The　cyclic　voltammograms　for　nearly　all　of　the　chalcone　oximes　investigated　exhibit　only　one　oxidation　peak.　On　the　basis　of　preparative　electrolysis　results　and　CV　analysis,　a　reaction　mechanism,　involving　a　combination　of　electrochemically-generated　base　and　an　iminoxy　radical　intermediate,　is　proposed.　(C)　2014　Elsevier　B.V.　All　rights　reserved.