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摘要：
Clinical applications of current photodynamic therapy (PDT) agents are often limited by their low singlet oxygen (O-1(2)) quantum yields, as well as by photobleaching and poor biocompatibility. Here we present a new PDT agent based on graphene quantum dots (GQDs) that can produce O-1(2) via a multistate sensitization process, resulting in a quantum yield of similar to 1.3, the highest reported for PDT agents. The GQDs also exhibit a broad absorption band spanning the UV region and the entire visible region and a strong deep-red emission. Through in vitro and in vivo studies, we demonstrate that GQDs can be used as PDT agents, simultaneously allowing imaging and providing a highly efficient cancer therapy. The present work may lead to a new generation of carbon-based nanomaterial PDT agents with overall performance superior to conventional agents in terms of O-1(2) quantum yield, water dispersibility, photo-and pH-stability, and biocompatibility.
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来源 ：
NATURE COMMUNICATIONS
ISSN： 2041-1723
年份： 2014
卷： 5
1 6 . 6 0 0
JCR@2022
ESI学科： Multidisciplinary;
ESI高被引阀值：297
JCR分区：1
中科院分区：1
