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Author:

Ge, Jiechao (Ge, Jiechao.) | Lan, Minhuan (Lan, Minhuan.) | Zhou, Bingjiang (Zhou, Bingjiang.) | Liu, Weimin (Liu, Weimin.) | Guo, Liang (Guo, Liang.) | Wang, Hui (Wang, Hui.) | Jia, Qingyan (Jia, Qingyan.) | Niu, Guangle (Niu, Guangle.) | Huang, Xing (Huang, Xing.) | Zhou, Hangyue (Zhou, Hangyue.) | Meng, Xiangmin (Meng, Xiangmin.) | Wang, Pengfei (Wang, Pengfei.) | Lee, Chun-Sing (Lee, Chun-Sing.) | Zhang, Wenjun (Zhang, Wenjun.) | Han, Xiaodong (Han, Xiaodong.) (Scholars:韩晓东)

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Scopus SCIE PubMed

Abstract:

Clinical applications of current photodynamic therapy (PDT) agents are often limited by their low singlet oxygen (O-1(2)) quantum yields, as well as by photobleaching and poor biocompatibility. Here we present a new PDT agent based on graphene quantum dots (GQDs) that can produce O-1(2) via a multistate sensitization process, resulting in a quantum yield of similar to 1.3, the highest reported for PDT agents. The GQDs also exhibit a broad absorption band spanning the UV region and the entire visible region and a strong deep-red emission. Through in vitro and in vivo studies, we demonstrate that GQDs can be used as PDT agents, simultaneously allowing imaging and providing a highly efficient cancer therapy. The present work may lead to a new generation of carbon-based nanomaterial PDT agents with overall performance superior to conventional agents in terms of O-1(2) quantum yield, water dispersibility, photo-and pH-stability, and biocompatibility.

Keyword:

Author Community:

  • [ 1 ] [Ge, Jiechao]Chinese Acad Sci, TIPC, Key Lab Photochem Convers & Optoelectron Mat, Beijing 100190, Peoples R China
  • [ 2 ] [Lan, Minhuan]Chinese Acad Sci, TIPC, Key Lab Photochem Convers & Optoelectron Mat, Beijing 100190, Peoples R China
  • [ 3 ] [Zhou, Bingjiang]Chinese Acad Sci, TIPC, Key Lab Photochem Convers & Optoelectron Mat, Beijing 100190, Peoples R China
  • [ 4 ] [Liu, Weimin]Chinese Acad Sci, TIPC, Key Lab Photochem Convers & Optoelectron Mat, Beijing 100190, Peoples R China
  • [ 5 ] [Guo, Liang]Chinese Acad Sci, TIPC, Key Lab Photochem Convers & Optoelectron Mat, Beijing 100190, Peoples R China
  • [ 6 ] [Wang, Hui]Chinese Acad Sci, TIPC, Key Lab Photochem Convers & Optoelectron Mat, Beijing 100190, Peoples R China
  • [ 7 ] [Jia, Qingyan]Chinese Acad Sci, TIPC, Key Lab Photochem Convers & Optoelectron Mat, Beijing 100190, Peoples R China
  • [ 8 ] [Niu, Guangle]Chinese Acad Sci, TIPC, Key Lab Photochem Convers & Optoelectron Mat, Beijing 100190, Peoples R China
  • [ 9 ] [Huang, Xing]Chinese Acad Sci, TIPC, Key Lab Photochem Convers & Optoelectron Mat, Beijing 100190, Peoples R China
  • [ 10 ] [Zhou, Hangyue]Chinese Acad Sci, TIPC, Key Lab Photochem Convers & Optoelectron Mat, Beijing 100190, Peoples R China
  • [ 11 ] [Meng, Xiangmin]Chinese Acad Sci, TIPC, Key Lab Photochem Convers & Optoelectron Mat, Beijing 100190, Peoples R China
  • [ 12 ] [Wang, Pengfei]Chinese Acad Sci, TIPC, Key Lab Photochem Convers & Optoelectron Mat, Beijing 100190, Peoples R China
  • [ 13 ] [Lee, Chun-Sing]City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Hong Kong 999077, Hong Kong, Peoples R China
  • [ 14 ] [Zhang, Wenjun]City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Hong Kong 999077, Hong Kong, Peoples R China
  • [ 15 ] [Lee, Chun-Sing]City Univ Hong Kong, Dept Phys & Mat Sci, Hong Kong 999077, Hong Kong, Peoples R China
  • [ 16 ] [Zhang, Wenjun]City Univ Hong Kong, Dept Phys & Mat Sci, Hong Kong 999077, Hong Kong, Peoples R China
  • [ 17 ] [Han, Xiaodong]Beijing Univ Technol, Inst Microstructure & Properties Adv Mat, Beijing 100124, Peoples R China

Reprint Author's Address:

  • [Wang, Pengfei]Chinese Acad Sci, TIPC, Key Lab Photochem Convers & Optoelectron Mat, Beijing 100190, Peoples R China

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Source :

NATURE COMMUNICATIONS

ISSN: 2041-1723

Year: 2014

Volume: 5

1 6 . 6 0 0

JCR@2022

ESI Discipline: Multidisciplinary;

ESI HC Threshold:297

JCR Journal Grade:1

CAS Journal Grade:1

Cited Count:

WoS CC Cited Count: 1219

SCOPUS Cited Count: 1277

ESI Highly Cited Papers on the List: 37 Unfold All

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WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 0

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