英文标题
Research on the classification method of α/βprotein fold type
英文摘要
The research of protein folding pattern is one of the major frontier subjects in life science, and folding is the basis of protein classification. Based on the LIFCA database, we selected research objects as 55 folding types ofα/β, whose sample sizes are larger than 2. Combining with the definition of protein folding and its conservative topology characteristics, we determined the templates of the 55 folding types as well as their corresponding characteristic parameters. Based on the templates, we built a scoring function: Mul-Fscore. In LIFAC database, based on testing of selected 931 proteins, the average specificity, sensitivity, and MCC values are 99.58%, 79.47% and 79.39%, respectively. Compared with TM-score, we found that the sensitivity and MCC values of Mul-Fscore are slightly better, while the average specificity is quite similar.
翻译关键词
LIFCA database
Scoring function
Protein of α/β
Folding type classification
获取号
WF:perioarticalswxxx201402008
