A　general　methodology　for　seismic　low-cycle　fatigue　assessment　of　welded　beam-to-column　connection　in　steel　moment　resisting　frames　(SMRFs)　is　presented.　Fatigue　deformability　curves　of　seven　connection　categories　are　elaborated　using　the　available　cyclic　tests.　Inter-storey　drift　history　imposed　on　each　connection　of　SMRF　is　generated　by　seismic　dynamic　analysis　and　adopted　in　fatigue　damage　calculation　based　on　Palmgren-Miner＇s　rule　and　the　experimentally　determined　fatigue　curve.　The　most　critical　connection　identified　by　preliminary　fatigue　evaluation　is　refined　with　solid　finite　elements　in　global　local　model　where　the　cyclic　void　growth　model　is　integrated　to　give　a　more　accurate　fatigue　prediction　including　load　sequence　effects.　The　proposed　approach　is　applicable　to　fatigue　evaluation　of　welded　connections　in　SMRFs　under　earthquakes.　(C)　2014　Elsevier　Ltd.　All　rights　reserved.