Background:　The　aim　of　this　study　was　to　determine　the　hemodynamic　effects　of　various　support　modes　of　continuous　flow　left　ventricular　assist　devices　(CF-LVADs)　on　the　cardiovascular　system　using　a　numerical　cardiovascular　system　model.　Material/Methods:　Three　support　modes　were　selected　for　controlling　the　CF-LVAD:　constant　flow　mode,　constant　speed　mode,　and　constant　pressure　head　mode　of　CF-LVAD.　The　CF-LVAD　is　established　between　the　left　ventricular　apex　and　the　ascending　aorta,　and　was　incorporated　into　the　numerical　model.　Various　parameters　were　evaluated,　including　the　blood　assist　index　(BAI),　the　left　ventricular　external　work　(LVEW),　the　energy　of　blood　flow　(EBF),　pulsatility　index　(PI),　and　surplus　hemodynamic　energy　(SHE).　Results:　The　results　show　that　the　constant　flow　mode,　when　compared　to　the　constant　speed　mode　and　the　constant　pressure　head　mode,　increases　LVEW　by　31%　and　14%,　and　EBF　by　21%　and　15%,　respectively,　indicating　that　this　mode　achieved　the　best　ventricular　unloading　among　the　3　support　modes.　As　BAI　is　increased,　PI　and　SHE　are　gradually　decreased,　whereas　PI　of　the　constant　pressure　head　reaches　the　maximum　value.　Conclusions:　The　study　demonstrates　that　the　continuous　flow　control　mode　of　the　CF-LVAD　may　achieve　the　highest　ventricular　unloading.　In　contrast,　the　constant　rotational　speed　mode　permits　the　optimal　blood　perfusion.　Finally,　the　constant　pressure　head　strategy,　permitting　optimal　pulsatility,　should　optimize　the　vascular　function.