The　ability　to　obtain　a　maximum　loading　of　inorganic　nanoparticles　while　maintaining　uniform　dispersion　in　the　polymer　is　the　key　to　the　fabrication　of　mixed-matrix　membranes　with　high　pervaporation　performance　in　bioalcohol　recovery　from　aqueous　solution.　Herein,　we　report　the　simultaneous　spray　self-assembly　of　a　zeolitic　imidazolate　framework　(ZIF)-polymer　suspension　and　a　cross-linker/catalyst　solution　as　a　method　for　the　fabrication　of　a　well-dispersed　ZIF-8-PDMS　nanohybrid　membrane　with　an　extremely　high　loading.　The　ZIF-8-PDMS　membrane　showed　excellent　biobutanol-permselective　pervaporation　performance.　When　the　ZIF-8　loading　was　increased　to　40　wt%,　the　total　flux　and　separation　factor　could　reach　4846.2　gm(-2)　h(-1)　and　81.6,　respectively,　in　the　recovery　of　n-butanol　from　1.0　wt%　aqueous　solution　(80　degrees　C).　This　new　method　is　expected　to　have　serious　implications　for　the　preparation　of　defect-free　mixed-matrix　membranes　for　many　applications.