To　observe　the　efficacy　of　intra-arterial　chemotherapy　with　subcutaneously　implanted　pump　for　soft　tissue　sarcoma　in　extremities　and　cancerous　ulcer.　31　patients　with　ulcerative　skin　squamous　cell　carcinoma　or　sarcoma　in　extremities　who　received　treatment　during　the　period　from　July　2003　to　November　2011　at　our　hospital　were　recruited,　including　15　male　and　16　female　patients,　aging　between　14　and　83　with　average　age　of　49　years　old.　10　patients　had　tumor　in　upper　extremities　and　21　patients　in　lower　extremities.　The　pathological　types　of　studied　cases　include　9　cases　with　skin　squamous　cell　carcinoma,　6　cases　with　synovial　sarcoma,　5　cases　with　malignant　fibrous　histiocytoma,　3　cases　with　liposarcoma,　3　cases　with　osteosarcoma,　2　cases　with　malignant　melanoma,　2　cases　with　epidermoid　sarcoma,　and　1　case　with　protuberans.　The　main　symptoms　of　cancerous　ulcer　were　pain,　infection　and　hemorrhage;　All　the　studied　patients　were　administrated　with　cisplatin　and　doxorubicin　by　intra-arterial　chemotherapy　pump,　and　the　patients　with　squamous　cell　carcinoma　were　additionally　applied　with　bleomycin　and　patients　with　malignant　melanoma　were　additionally　applied　with　dacarbazine.　The　chemotherapy　efficiency　was　observed　after　at　3　cycles　of　intra-arterial　chemotherapy.　The　total　remission　rate　of　pain　(RR)　was　87　%,　and　total　remission　rate　of　ulcer　cicatrization　(RR)　was　71　%,　with　ulcer　cicatrizing　spontaneously　in　9　cases　and　obvious　homeostasis　in　5　cases　with　bleeding　ulcers.　19　patients　underwent　surgery　after　chemotherapy,　in　which　16　cases　had　limb-salvage　surgery　and　3　cases　underwent　lower　leg　amputation　after　chemotherapy,　and　3　patients　out　of　16　cases　had　local　recurrence　(19　%).　The　subcutaneous　intra-arterial　targeting　chemotherapy　could　be　applied　to　treat　refractory　sarcoma　and　cancerous　ulcer　in　extremities　to　significantly　increase　the　chemotherapeutic　concentration　at　tumor　area　so　as　to　effectively　constrain　the　tumor　rupture　induced　main　symptoms　including　pain,　infection　and　bleeding,　which　would　help　to　make　a　decreased　blood　supplied　and　well　defined　tumor　boundary　to　finally　decrease　the　recurrence　rate.