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作者:

Zhang, X. C. (Zhang, X. C..) | Liu, S. Q. (Liu, S. Q..) | Ren, H. X. (Ren, H. X..) | Zeng, Y. J. (Zeng, Y. J..) | Zhan, G. X. (Zhan, G. X..)

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Scopus SCIE

摘要:

In the cerebellum, long-term depression (LTD) plays a key function in sculpting neuronal circuits to store information, since motor learning and memory are thought to be associated with such long-term changes in synaptic efficacy. To better understand the principles of transmission of information in the cerebellum, we, in our model, distinguished different types of neurons (type 1- and type 2-like) to examine the neuronal excitability and analyze the interspike interval (ISI) bifurcation phenomenon in these units, and then built a Purkinje cell circuit to study the impact of external stimulation on LTD in this circuit. According to the results of computational analysis, both climbing fiber-Purkinje cell and granule cell-Purkinje cell circuits were found to manifest LTD; the external stimuli would influence LTD by changing both depression time and depression intensity. All of the simulated results showed that LTD is a very significant factor in the Purkinje circuit networks. Finally, to deliver the learning regularities, we simulated spike timing-dependent plasticity (STDP) by increasing the CaP conductance.

关键词:

depression intensity depression time interspike interval (ISI) ion currents long-term depression (LTD) spike timing-dependent plasticity (STDP)

作者机构:

  • [ 1 ] [Zhang, X. C.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China
  • [ 2 ] [Liu, S. Q.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China
  • [ 3 ] [Ren, H. X.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China
  • [ 4 ] [Zhan, G. X.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China
  • [ 5 ] [Zeng, Y. J.]Beijing Univ Technol, Ctr Biomed Engn, Beijing, Peoples R China

通讯作者信息:

  • [Zhang, X. C.]S China Univ Technol, Dept Math, Guangzhou, Guangdong, Peoples R China

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来源 :

NEUROPHYSIOLOGY

ISSN: 0090-2977

年份: 2014

期: 1

卷: 46

页码: 25-32

0 . 5 0 0

JCR@2022

ESI学科: NEUROSCIENCE & BEHAVIOR;

ESI高被引阀值:196

JCR分区:4

中科院分区:4

被引次数:

WoS核心集被引频次: 0

SCOPUS被引频次:

ESI高被引论文在榜: 0 展开所有

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