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作者:

Ji, Junzhong (Ji, Junzhong.) (学者:冀俊忠) | Zhang, Aidong (Zhang, Aidong.) | Liu, Chunnian (Liu, Chunnian.) | Quan, Xiaomei (Quan, Xiaomei.) | Liu, Zhijun (Liu, Zhijun.)

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EI Scopus SCIE

摘要:

A protein-protein interaction (PPI) network is a biomolecule relationship network that plays an important role in biological activities. Studies of functional modules in a PPI network contribute greatly to the understanding of biological mechanism. With the development of life science and computing science, a great amount of PPI data has been acquired by various experimental and computational approaches, which presents a significant challenge of detecting functional modules in a PPI network. To address this challenge, many functional module detecting methods have been developed. In this survey, we first analyze the existing problems in detecting functional modules and discuss the countermeasures in the data preprocess and postprocess. Second, we introduce some special metrics for distance or graph developed in clustering process of proteins. Third, we give a classification system of functional module detecting methods and describe some existing detection methods in each category. Fourth, we list databases in common use and conduct performance comparisons of several typical algorithms by popular measurements. Finally, we present the prospects and references for researchers engaged in analyzing PPI networks.

关键词:

clustering algorithm computation approach functional module detection Protein-protein interaction network

作者机构:

  • [ 1 ] [Ji, Junzhong]Beijing Univ Technol, Beijing Municipal Key Lab Multimedia & Intelligen, Coll Comp Sci & Technol, Beijing 100124, Peoples R China
  • [ 2 ] [Liu, Chunnian]Beijing Univ Technol, Beijing Municipal Key Lab Multimedia & Intelligen, Coll Comp Sci & Technol, Beijing 100124, Peoples R China
  • [ 3 ] [Quan, Xiaomei]Beijing Univ Technol, Beijing Municipal Key Lab Multimedia & Intelligen, Coll Comp Sci & Technol, Beijing 100124, Peoples R China
  • [ 4 ] [Liu, Zhijun]Beijing Univ Technol, Beijing Municipal Key Lab Multimedia & Intelligen, Coll Comp Sci & Technol, Beijing 100124, Peoples R China
  • [ 5 ] [Zhang, Aidong]SUNY Buffalo, Dept Comp Sci & Engn, Buffalo, NY 14260 USA

通讯作者信息:

  • 冀俊忠

    [Ji, Junzhong]Beijing Univ Technol, Beijing Municipal Key Lab Multimedia & Intelligen, Coll Comp Sci & Technol, 100 Ping Leyuan, Beijing 100124, Peoples R China

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来源 :

IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING

ISSN: 1041-4347

年份: 2014

期: 2

卷: 26

页码: 261-277

8 . 9 0 0

JCR@2022

ESI学科: ENGINEERING;

ESI高被引阀值:123

JCR分区:1

中科院分区:2

被引次数:

WoS核心集被引频次: 76

SCOPUS被引频次: 92

ESI高被引论文在榜: 0 展开所有

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中文被引频次:

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