Objective:　The　purpose　of　this　study　was　to　analyze　the　effects　of　fatigue　driving　and　drunk　driving　on　drivers＇　physical　characteristics;　to　analyze　the　differences　in　drivers＇　physical　characteristics　affected　by　different　kinds　of　fatigue;　and　to　compare　the　differences　in　the　effects　of　the　2　driving　states,　fatigue　driving　and　drunk　driving.　Methods:　Twenty-five　participants＇　physical　characteristics　were　collected　under　5　controlled　situations:　normal,　tired　driving,　drowsy　driving,　drowsiness　+　tired　driving,　and　drunk　driving.　In　this　article,　fatigue　driving　refers　to　tiredness　and　drowsiness　and　includes　3　situations:　tired　driving,　drowsy　driving,　and　drowsiness　+　tired　driving.　The　drivers＇　physical　characteristics　were　measured　in　terms　of　9　parameters:　systolic　blood　pressure　(SBP),　heart　rate　(HR),　eyesight,　dynamic　visual　acuity　(DVA),　time　for　dark　adaption　(TDA),　reaction　time　to　sound　(RTS),　reaction　time　to　light　(RTL),　deviation　of　depth　perception　(DDP),　and　time　deviation　of　speed　anticipation　(TDSA).　They　were　analyzed　using　analysis　of　variance　(ANOVA)　with　repeated　measures.　Binary　logistical　regression　analysis　was　used　to　explain　the　relationship　between　drivers＇　physical　characteristics　and　the　two　driving　states.　Results:　Most　of　the　drivers＇　physical　characteristic　parameters　were　found　to　be　significantly　different　under　the　influence　of　different　situations.　Four　indicators　are　significantly　affected　by　fatigue　driving　during　deep　fatigue　(in　decreasing　order　of　influence):　HR,　RTL,　SBP　and　RTS.　HR　and　RTL　are　significant　in　the　logistical　regression　model　of　the　drowsiness　+　tired　driving　situation　and　normal　situations.　Six　indicators　of　the　drivers＇　physical　characteristics　are　significantly　affected　by　drunk　driving　(in　decreasing　order　of　influence):　SBP,　RTL,　DDP,　eyesight,　RTS,　and　TDSA.　SBP　and　DDP　have　a　significant　effect　in　the　logistical　regression　model　of　the　drunk　driving　situation　and　the　normal　situation.　Conclusions:　Both　fatigue　driving　and　drunk　driving　are　found　to　impair　drivers＇　physical　characteristics.　However,　their　impacts　on　the　parameters　SBP,　HR,　eyesight,　and　TDSA　are　different.　A　driver＇s　physical　characteristics　will　be　impaired　more　seriously　when　he　continues　driving　while　drowsy,　compared　to　driving　under　normal　situation.　These　findings　contribute　to　the　current　research　on　identifying　drivers＇　driving　state　and　quantifying　the　effects　of　fatigue　driving　and　drunk　driving　on　driving　ability　and　driving　behavior.