We　propose　and　experimentally　demonstrate　a　shift-multiplexing　complex　spectral-domain　optical　coherence　tomography　(shift-multiplexing　CSD-OCT)　method,　in　which　the　maximum　detection　depth　of　SD-OCT　can　be　greatly　extended　by　incorporating　the　shift-multiplexing　of　detection　positions　with　CSD-OCT.　The　tomographic　imaging　with　twofold　or　threefold　microscopic　slides　as　the　target　sample　is　performed.　The　experimental　results　show　that　the　tomographic　imaging　with　more　uniform　brightness　and　clarity　for　the　different　depth　regions　in　a　thick　sample　can　be　achieved　by　the　shift-multiplexing　CSD-OCT　system.　In　particular,　even　while　the　sample＇s　depth　is　beyond　the　maximum　imaging　depth　of　CSD-OCT　system,　the　tomographic　imaging　of　this　sample　can　still　be　realized　by　using　the　shift-multiplexing　CSD-OCT　method　without　the　need　for　any　replacement　of　the　equipment,　such　as　high　spectral　capacity　grating　or　high　resolution　of　CCD.　The　shift-multiplexing　CSD-OCT　system　can　perform　the　imaging　with　the　optimization　and　less　reduction　of　sensitivity　for　the　deeper　detection　position　in　the　sample.　(C)　The　Authors.　Published　by　SPIE　under　a　Creative　Commons　Attribution　3.0　Unported　License.　Distribution　or　reproduction　of　this　work　in　whole　or　in　part　requires　full　attribution　of　the　original　publication,　including　its　DOI.