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摘要:
The expression of miR-203 has been reported to be significantly down-regulated in esophageal cancer. We showed here that overexpression of miR-203 in esophageal cancer cells dramatically increased cell apoptosis and inhibited cell proliferation, migration and invasion as well as tumor growth and down-regulated miR-21 expression. We subsequently identified that small GTPase Ran was a target gene of miR-203. Furthermore, Ran restoration partially counteracted the tumor suppressive effects of miR-203 and increased miR-21 expression. Taken together, our findings suggest that miR-203 may act as novel tumor suppressor in esophageal cancer through down-regulating the expression of Ran and miR-21. (C) 2013 Elsevier Ireland Ltd. Published by Elsevier Ltd. All rights reserved.
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来源 :
CANCER LETTERS
ISSN: 0304-3835
年份: 2014
期: 1
卷: 342
页码: 121-129
9 . 7 0 0
JCR@2022
ESI学科: CLINICAL MEDICINE;
ESI高被引阀值:164
JCR分区:1
中科院分区:2