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作者:

Wang, Xiaohong (Wang, Xiaohong.) | Li, Xiaoyang (Li, Xiaoyang.)

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摘要:

Cerebral aneurysm is an irreversible dilatation causing intracranial haemorrhage with severe complications. It is assumed that the biomechanical factor plays a significant role in the development of cerebral aneurysm. However, reports on the correlations between the formation of intraluminal thrombus and the flow pattern, wall shear stress (WSS) distribution of the cerebral aneurysm as well as wall compliance are still limited. In this research, patient-specific numerical simulation was carried out for three cerebral aneurysms based on magnetic resonance imaging (MRI) data-sets. The interaction between pulsatile blood and aneurysm wall was taken into account. The biomechanical behaviour of cerebral aneurysm and its relation with the formation of intraluminal thrombus was studied systematically. The results of the numerical simulation indicated that the region of low blood flow velocity and the region of swirling recirculation were nearly coincident with each other. Besides, there was a significant correlation between the slow swirling flow and the location of thrombus deposition. Excessively low WSS was also found to have strong association with the regions of thrombus formation. Moreover, the relationship between cerebral aneurysm compliance and thrombus deposition was discovered. The patient-specific modelling study based on fluid-structure interaction) may provide a basis for future investigation on the prediction of thrombus formation in cerebral aneurysm.

关键词:

biomechanical behaviour cerebral aneurysm compliance deformation flow pattern wall shear stress

作者机构:

  • [ 1 ] [Wang, Xiaohong]Beijing Univ Technol, Coll Mech Engn & Appl Elect Technol, Biomech Res Lab, Beijing, Peoples R China
  • [ 2 ] [Li, Xiaoyang]Beijing Univ Technol, Coll Mech Engn & Appl Elect Technol, Biomech Res Lab, Beijing, Peoples R China

通讯作者信息:

  • [Wang, Xiaohong]Beijing Univ Technol, Coll Mech Engn & Appl Elect Technol, Biomech Res Lab, 100 Pingleyuan, Beijing, Peoples R China

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来源 :

COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING

ISSN: 1025-5842

年份: 2013

期: 11

卷: 16

页码: 1127-1134

1 . 6 0 0

JCR@2022

ESI学科: COMPUTER SCIENCE;

ESI高被引阀值:136

JCR分区:2

中科院分区:3

被引次数:

WoS核心集被引频次: 9

SCOPUS被引频次: 11

ESI高被引论文在榜: 0 展开所有

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