Ultrasonic　harmonic　scalpel　has　been　widely　applied　to　laparoscopic　surgery　of　gastric　cancer,　but　it　has　not　been　evaluated　properly　in　open　surgery.　The　objective　of　this　study　was　to　evaluate　the　value　of　the　ultrasonic　harmonic　scalpel　in　the　open　radical　surgery　of　gastric　cancer.　106　gastric　cancer　patients　who　had　accepted　distal　D2　lymphadenectomy　were　included　in　this　study.　Patients　were　divided　into　ultrasonic　harmonic　scalpel　(UHS)　surgery　group　(50　cases)　and　conventional　electric　scalpel　surgery　group　(56　cases).　UHS　surgery　group　patients　were　accepted　surgery　by　ultrasonic　harmonic　scalpel.　Instead,　conventional　electric　scalpel　surgery　group　patients　were　accepted　surgery　by　monopolar　electrocautery　shovel　and　other　traditional　instruments.　Then　the　average　operation　time,　intra-operative　blood　loss,　number　of　harvested　lymph　nodes,　average　post　operative　drainage　within　3　days,　and　postoperative　hospital　stay　were　collected　and　compared　between　the　two　groups.　The　average　operation　time,　blood　loss,　postoperative　hospital　stay　in　UHS　group　were　significantly　lower　than　traditional　group　(P　＜　0.05).　The　number　of　lymph　node　dissection　was　significantly　higher　than　conventional　surgery　group　(P　＜　0.05).　There　were　no　difference　between　two　groups　in　average　drainage　within　3　days　after　surgery　and　the　hospitalization　costs　(P　＞　0.05).　In　the　presence　of　atherosclerotic　patients,　the　average　operation　time,　blood　loss　in　UHS　surgery　group　were　significantly　lower　than　the　traditional　group　(P　＜　0.05).　Ultrasonic　harmonic　scalpel　may　have　better　effect　in　the　radical　surgery　of　gastric　cancer　patients.　It　meets　the　requirements　of　the　future　development　of　precise　surgical　procedure.