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作者:

Xiang, Jie (Xiang, Jie.) | Guo, Hao (Guo, Hao.) | Cao, Rui (Cao, Rui.) | Liang, Hong (Liang, Hong.) | Chen, Junjie (Chen, Junjie.)

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摘要:

Brain structure and cognitive function change in the temporal lobe, hippocampus, and prefrontal cortex of patients with mild cognitive impairment and Alzheimer's disease, and brain network-connection strength, network efficiency, and nodal attributes are abnormal. However, existing research has only analyzed the differences between these patients and normal controls. In this study, we constructed brain networks using resting-state functional MRI data that was extracted from four populations (normal controls, patients with early mild cognitive impairment, patients with late mild cognitive impairment, and patients with Alzheimer's disease) using the Alzheimer's Disease Neuroimaging Initiative data set. The aim was to analyze the characteristics of resting-state functional neural networks, and to observe mild cognitive impairment at different stages before the transformation to Alzheimer's disease. Results showed that as cognitive deficits increased across the four groups, the shortest path in the resting-state functional network gradually increased, while clustering coefficients gradually decreased. This evidence indicates that dementia is associated with a decline of brain network efficiency. In addition, the changes in functional networks revealed the progressive deterioration of network function across brain regions from healthy elderly adults to those with mild cognitive impairment and Alzheimer's disease. The alterations of node attributes in brain regions may reflect the cognitive functions in brain regions, and we speculate that early impairments in memory, hearing, and language function can eventually lead to diffuse brain injury and other cognitive impairments.

关键词:

aging Alzheimer's disease diffuse brain disease early mild cognitive impairment functional MRI grants-supported paper graph theory human connectonne late mild cognitive impairment neural regeneration neurodegeneration neuroregeneration resting state small world property

作者机构:

  • [ 1 ] [Xiang, Jie]Taiyuan Univ Technol, Coll Comp Sci & Technol, Taiyuan 030024, Shanxi Province, Peoples R China
  • [ 2 ] [Guo, Hao]Taiyuan Univ Technol, Coll Comp Sci & Technol, Taiyuan 030024, Shanxi Province, Peoples R China
  • [ 3 ] [Cao, Rui]Taiyuan Univ Technol, Coll Comp Sci & Technol, Taiyuan 030024, Shanxi Province, Peoples R China
  • [ 4 ] [Liang, Hong]Taiyuan Univ Technol, Coll Comp Sci & Technol, Taiyuan 030024, Shanxi Province, Peoples R China
  • [ 5 ] [Chen, Junjie]Taiyuan Univ Technol, Coll Comp Sci & Technol, Taiyuan 030024, Shanxi Province, Peoples R China
  • [ 6 ] [Xiang, Jie]Beijing Univ Technol, Int WIC Inst, Beijing 100022, Peoples R China

通讯作者信息:

  • [Chen, Junjie]Taiyuan Univ Technol, Coll Comp Sci & Technol, Taiyuan 030024, Shanxi Province, Peoples R China

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来源 :

NEURAL REGENERATION RESEARCH

ISSN: 1673-5374

年份: 2013

期: 30

卷: 8

页码: 2789-2799

6 . 1 0 0

JCR@2022

ESI学科: NEUROSCIENCE & BEHAVIOR;

ESI高被引阀值:224

JCR分区:4

中科院分区:4

被引次数:

WoS核心集被引频次: 38

SCOPUS被引频次: 41

ESI高被引论文在榜: 0 展开所有

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中文被引频次:

近30日浏览量: 2

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