A　family　of　novel　axially　unfixed　biaryl-based,　water-compatible　bifunctional　organocatalysts　were　designed　and　synthesized　for　asymmetric　catalytic　direct　aldol　reactions　in　water.　These　organocatalysts　are　comprised　of　prolinamide,　aromatic　sulfonamide　and　biaryl　motifs.　Under　the　optimal　reaction　conditions,　one　organocatalyst　in　particular　delivered　excellent　stereocontrol　(up　to　99%　ee　and　99:1　dr)　in　direct　aldol　reactions　of　cyclohexanone　with　a　variety　of　aromatic　aldehydes　in　water.