Fracture　assessment　of　the　cracked　structures　is　essential　to　avoiding　fracture　failure.　A　number　of　fracture　assessment　procedures　have　been　proposed　for　various　steel　structures.　However,　the　studies　about　the　application　of　available　procedures　for　titanium　alloy　structures　are　scarcely　reported.　Fracture　assessment　for　the　electron　beam(EB)　welded　thick-walled　damage　tolerant　Ti-6Al-4V(TC4-DT)　alloy　is　performed　by　the　fitness-for-service(FFS)　FITNET　procedure.　Uniaxial　tensile　tests　and　fracture　assessment　tests　of　the　base　metal　and　weld　metal　are　carried　out　to　obtain　the　input　information　of　assessment.　The　standard　options　and　advanced　options　of　FITNET　FFS　procedure　are　used　to　the　fracture　assessment　of　the　present　material.　Moreover,　the　predicted　maximum　loads　of　compact　tensile　specimen　using　FITNET　FFS　procedure　are　verified　with　the　experimental　data　of　fracture　assessment　tests.　As　a　result,　it　is　shown　that　the　mechanical　properties　of　weld　metal　are　inhomogeneous　along　the　weld　depth.　The　mismatch　ratio　M　is　less　than　10%　at　the　weld　top　and　middle,　whereas　more　than　10%　at　the　weld　bottom.　Failure　assessment　lines　of　standard　options　are　close　to　that　of　advanced　option,　which　means　that　the　standard　options　are　suitable　for　fracture　assessment　of　the　present　welds.　The　accurate　estimation　of　the　maximum　loads　has　been　obtained　by　fracture　assessment　of　standard　options　with　error　less　than　6%.　Furthermore,　there　are　no　potential　advantages　of　applying　higher　options　or　mismatch　options.　Thus,　the　present　welded　joints　can　be　treated　as　homogeneous　material　during　the　fracture　assessment,　and　standard　option　1　can　be　used　to　achieve　accurate　enough　results.　This　research　provides　the　engineering　treatment　methods　for　the　fracture　assessment　of　titanium　alloy　and　its　EB　welds.