A　steel-concrete　composite　frame　is　typically　used　for　building　construction.　Earthquake　action　and　progressive　collapse　event　caused　by　accidental　local　failures　are　the　primary　threats　affecting　the　safety　of　steel-concrete　composite　frames.　Currently,　multi-hazard　resistance　and　building　resilience　have　garnered　much　research　attention　from　the　international　civil　engineering　community.　Based　on　the　previously　proposed　first-generation　seismic　and　progressive　collapse　resistant　composite　frame　(SPCRCF),　an　improved　second-generation　seismic　and　progressive　collapse　resilient　steel-concrete　composite　frame　(SPCRCF-2)　is　proposed.　The　performance　of　SPCRCF-2　is　compared　with　that　of　SPCRCF　as　well　as　a　conventional　steel-concrete　composite　frame　(CSCCF)　through　seismic　and　progressive　collapse　experiments.　Compared　with　CSCCF　and　SPCRCF,　SPCRCF-2　is　proven　to　be　able　to　localize　the　damage　to　the　replaceable　energy-dissipating　(ED)　components　under　both　seismic　and　progressive　collapse　conditions,　whilst　maintaining　the　other　key　components　(beams　and　columns)　damage-free.　This　special　feature　facilitates　rapid　repair　of　the　structure　thereby　achieving　multi-hazard　resilience.　Finally,　theoretical　models　are　proposed　to　calculate　the　initial　stiffness　and　flexural　yield　strength　of　the　beam-column　joint　connection　in　SPCRCF-2.　The　models　are　further　validated　by　the　experimental　results.