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作者:

Zhu, Yanzhen (Zhu, Yanzhen.) | Zeng, Yanjun (Zeng, Yanjun.) | Wang, Xuan (Wang, Xuan.) | Ye, Xiaobao (Ye, Xiaobao.)

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Scopus SCIE

摘要:

Clinically, electroacupuncture is proved to be an effective therapy for vascular dementia; however, their mechanisms remain uncertain. The aim of the current study was to investigate the mechanism of electroacupuncture therapy for vascular dementia. One month after a vascular dementia animal model was established by bilateral occlusion of common carotid arteries, electroacupuncture treatment was given at "Baihui" (DU20), "Dazhui" (DU14), and "Shenshu" (BL23). Morris water maze was used to assess the learning and memory ability of rats. Western blot assay was performed to detect the expression of mammalian target of rapamycin (mTOR) and eukaryotic translation initiation factor 4E (eIF4E) in hippocampus of rats. Morris water maze test showed that electroacupuncture improved the learning ability of vascular dementia rats. Western blot assay revealed that the expression level of mTOR and eIF4E in the electroacupuncture group and sham-operated group was higher than that in the vascular dementia group (P < 0.05). In conclusion, the decreasing expression of mTOR and eIF4E plays important roles in the pathogenesis of vascular dementia. Electroacupuncture improves learning and memory ability by up-regulating expression of mTOR and eIF4E in the hippocampus of vascular dementia rats.

关键词:

eIF4E Electroacupuncture Hippocampus mTOR Vascular dementia

作者机构:

  • [ 1 ] [Zhu, Yanzhen]Fujian Univ Tradit Chinese Med, Dept Integrat Med, Fuzhou 350122, Fujian, Peoples R China
  • [ 2 ] [Ye, Xiaobao]Fujian Univ Tradit Chinese Med, Dept Integrat Med, Fuzhou 350122, Fujian, Peoples R China
  • [ 3 ] [Zeng, Yanjun]Beijing Univ Technol, Biomech & Med Informat Inst, Beijing 100022, Peoples R China
  • [ 4 ] [Wang, Xuan]Fujian Univ Tradit Chinese Med, Dept Acupuncture & Tuina, Fuzhou 350122, Fujian, Peoples R China

通讯作者信息:

  • [Zeng, Yanjun]Beijing Univ Technol, Biomech & Med Informat Inst, Beijing 100022, Peoples R China

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来源 :

NEUROLOGICAL SCIENCES

ISSN: 1590-1874

年份: 2013

期: 7

卷: 34

页码: 1093-1097

3 . 3 0 0

JCR@2022

ESI学科: NEUROSCIENCE & BEHAVIOR;

ESI高被引阀值:224

JCR分区:3

中科院分区:4

被引次数:

WoS核心集被引频次: 24

SCOPUS被引频次: 24

ESI高被引论文在榜: 0 展开所有

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中文被引频次:

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