The　research　and　development　of　calixarenes,　cyclodextrins　and　fullerenes,　which　constitute　the　major　classes　of　supramolecular　organic　host　compounds,　have　been　quite　rapidly　developing,　increasingly　active　and　newly　rising　highlight　interdisciplinary　fields.　Numerous　efforts　have　been　directed　toward　such　molecules　as　new　platforms　for　anti-HIV　drug　design.　This　work　briefly　reviewed　the　recent　development　of　calixarenes,　cyclodextrins　and　fullerenes　as　new　chemical　entities　of　distinct　anti-HIV　activities.　It　is　hoped　that　this　review　will　serve　as　a　stimulant　for　new　thoughts　in　the　quest　for　rational　designs　of　more　active　and　less　toxic　biological　molecules　as　anti-HIV　drugs.