Objective:　To　investigate　the　effect　of　simvastatin　on　the　biomechanical　characteristics　of　the　femur　in　ovariectomized　rats.　Material　and　methods:　Fifty-four　female　Sprague-Dawley　rats,　aged　three　months　old,　were　randomly　divided　into　three　groups:　sham-operated　group　(SHAM;　n　=　18),　ovariectomized　group　(OVX;　n　=　18),　and　ovariectomized　with　simvastatin　treatment　group　(OVX+SIM;　n　=　18).　Eight　weeks　after　being　ovariectomized,　simvastatin　was　administered　orally　at　5　mg/kg　each　day　in　the　OVX+SIM　group.　The　animals　were　sacrificed　at　either　four　or　12　weeks　after　administration　and　femurs　were　obtained.　Biomechanical　parameters　were　measured　by　the　three-point　bending　test.　Results:　There　were　no　significant　differences　in　the　maximal　strain　and　flexibility　strain　between　the　OVX　and　OVX+SIM　groups　at　either　four　or　12　weeks　after　administration　(p　＞　0.05).　In　contrast,　significant　differences　in　flexibility　loading　at　four　weeks　and　in　maximal　loading,　flexibility　loading,　and　the　coefficient　of　bending　ductility　between　the　OVX　and　OVX+SIM　groups　at　either　four　or　12　weeks　(p　＜　0.05　and　p　＜　0.01,　respectively).　Intergroup　comparisons　showed　that　maximal　loading　and　flexibility　loading　have　significant　differences　in　the　OVX+SIM　group　(p　＜　0.01).　Conclusion:　Simvastatin　shows　potential　in　promoting　bone　remodeling,　changing　bone　micro-architecture,　and　influencing　the　integration　and　distribution　ratio　of　organic　and　inorganic　constituents　in　bone　tissue　of　ovariectomized　rats.　In　addition,　a　longer　time　of　administration　with　simvastatin　could　enhance　the　femoral　strength.