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作者:

Ding, Jinli (Ding, Jinli.) | Liu, Youjun (Liu, Youjun.) (学者:刘有军) | Chai, Linjuan (Chai, Linjuan.) | Cao, Xue (Cao, Xue.) | Wang, Feng (Wang, Feng.)

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EI Scopus SCIE

摘要:

Tetralogy of Fallot is the most common cyanotic congenital heart defect. For severe cases, inserting a systemic to pulmonary shunt, which distributes part of systemic artery blood into the pulmonary artery, is the preferable palliative surgery. Based on the computed tomography images and three-dimensional geometry technologies, two patient-specific anatomical options of systemic to pulmonary shunts including the aorta to pulmonary shunt (APS) and innominate artery to pulmonary shunt (IPS) have been simulated for computational fluid dynamics. The objective of this study was to predict the hemodynamics within the shunts and con firm, through patient-specific simulations, the shunt with the optimal performance. Results indicated that both options created high velocity gradients and pressure gradients at the proximal end of the shunts. Obvious flow recirculation appeared at the inner region near the proximal end of the shunts. Part of the reverse flow from the descending aorta, left subclavian artery, left carotid artery and innominate artery was driven into the shunts during the diastolic period. The IPS provided better balanced and more adequate blood flow distributions between the systemic and pulmonary circulations. The APS provided slightly excessive pulmonary blood flow which can ultimately result in cardiac failure and pulmonary hypertension.

关键词:

computational fluid dynamics patient-specific systemic to pulmonary shunt Tetralogy of Fallot

作者机构:

  • [ 1 ] [Ding, Jinli]Beijing Univ Technol, Ctr Biomed Engn, Beijing 100124, Peoples R China
  • [ 2 ] [Liu, Youjun]Beijing Univ Technol, Ctr Biomed Engn, Beijing 100124, Peoples R China
  • [ 3 ] [Chai, Linjuan]Beijing Univ Technol, Ctr Biomed Engn, Beijing 100124, Peoples R China
  • [ 4 ] [Cao, Xue]Beijing Univ Technol, Ctr Biomed Engn, Beijing 100124, Peoples R China
  • [ 5 ] [Wang, Feng]Beijing Univ Technol, Ctr Biomed Engn, Beijing 100124, Peoples R China

通讯作者信息:

  • 刘有军

    [Liu, Youjun]Beijing Univ Technol, Ctr Biomed Engn, Beijing Pingleyuan 100, Beijing 100124, Peoples R China

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来源 :

JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY

ISSN: 0219-5194

年份: 2013

期: 1

卷: 13

0 . 8 0 0

JCR@2022

ESI学科: MOLECULAR BIOLOGY & GENETICS;

ESI高被引阀值:370

JCR分区:4

中科院分区:4

被引次数:

WoS核心集被引频次: 3

SCOPUS被引频次: 6

ESI高被引论文在榜: 0 展开所有

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中文被引频次:

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