Intra-aorta　pump　is　a　novel　rotary　ventricular　assist　device.　Because　of　the　special　structure　and　connection　with　the　native　heart,　the　hemodynamic　effect　of　support　mode　of　this　pump　on　the　cardiovascular　system　is　not　clear.　In　this　work,　three　support　modes,　including　constant　speed　mode,　co-pulse　mode,　and　counter-pulse　mode,　have　been　designed　for　the　intra-aorta　pump　to　evaluate　the　hemodynamic　effect　of　different　support　modes　on　the　cardiovascular　system.　Simulation　results　demonstrate　that　that　both　co-pulse　mode　and　counter-pulse　mode　can　achieve　better　unloading　performance　than　constant　speed　mode.　The　intra-aorta　pump　controlled　by　co-pulse　mode　is　beneficial　for　improving　coronary　flow.　Moreover,　the　external　work,　which　is　defined　as　the　product　of　left　ventricular　pressure　and　cardiac　output,　under　co-pulse　mode　is　the　minimum　of　the　three　support　modes　(0.783w　vs.　0.615w　vs.　0.702w).　The　pulsatility　ratio,　defined　as　the　ratio　of　the　peak-to-peak　value　of　arterial　pressure　(AP)　to　the　mean　arterial　pressure　value,　under　co-pulse　mode　is　the　maximum　of　the　three　modes　(24%　vs.　32.8%　vs.　23.7%).　The　equivalent　afterload　value,　which　is　the　ratio　of　pulsatile　pressure　at　the　pump　inflow　and　pulsatile　pump　flow,　is　larger　than　other　support　modes　(0.596mmHg.s/mL　vs.　0.9704mmHg.s/mL　vs.　0.55mmHg.s/mL).　In　brief,　the　intra-aorta　pump　under　co-pulse　mode　support　is　beneficial　for　improving　myocardial　perfusion　and　restoring　pulsatility　of　AP,　while　counter-pulse　mode　is　beneficial　to　the　perfusion　of　vital　organs.