Objective.　To　examine　the　biocompatibility　of　a　novel　nanohydroxyapatite/poly[lactic-co-glycolic　acid]　(nHA/PLGA)　composite　and　evaluate　its　feasibility　as　a　scaffold　for　cartilage　tissue　engineering.　Methods.　Chondrocytes　of　fetal　rabbit　were　cultured　with　nHA/PLGA　scaffold　in　vitro　and　the　cell　viability　was　assessed　by　MTT　assay　first.　Cells　adhering　to　nHA/PLGA　scaffold　were　then　observed　by　inverted　microscope　and　scanning　electron　microscope　(SEM).　The　cell　cycle　profile　was　analyzed　by　flow　cytometry.　Results.　The　viability　of　the　chondrocytes　on　the　scaffold　was　not　affected　by　nHA/PLGA　comparing　with　the　control　group　as　it　was　shown　by　MTT　assay.　Cells　on　the　surface　and　in　the　pores　of　the　scaffold　increased　in　a　time-dependent　manner.　Results　obtained　from　flow　cytometry　showed　that　there　was　no　significant　difference　in　cell　cycle　profiles　between　the　coculture　group　and　control　(P　＞　0.05).　Conclusion.　The　porous　nHA/PLGA　composite　scaffold　is　a　biocompatible　and　good　kind　of　scaffold　for　cartilage　tissue　engineering.