A　novel　and　efficient　copper-catalyzed　one-pot　synthesis　of　indoloimidazoquinoline　derivatives　has　been　developed.　The　protocol　uses　the　readily　available　substituted　2-(2-bromophenyl)-1H-indoles,　imidazole　and　benzoimidazoles　as　the　starting　materials,　inexpensive　CuBr　as　the　catalyst,　air　as　the　terminal　oxidant,　and　the　procedure　underwent　a　sequential　copper-catalyzed　intermolecular　N-arylation　and　an　aerobic　oxidative　intramolecular　C-H/C-H　coupling.