Further　development　of　metal-organic　frameworks　(MOFs)　requires　an　establishment　of　hierarchical　interaction　within　the　framework.　Herein,　we　report　a　series　of　mesoporous　rare-earth　(RE)　MOFs　that　are　constructed　from　an　unusual　12-connected　pi-stacked　pyrene　secondary　building　unit　(SBU)　and　a　typical　12-connected　RE6　cluster　(RE=Eu,　Y,　Yb,　Tb,　Ce).　The　judicious　design　of　a　butterfly-shape　pyrene　ligand　with　a　tert-butyl　substituent　enables　the　formation　of　the　disordered　12-connected　organic　SBUs　on　its　strong　intermolecular　pi-pi　interactions.　The　assembly　of　12-connected　inorganic　cuboctahedron　SBUs　and　12-connected　organic　distorted　hexagonal　prism　SBUs　generates　an　unprecedented　network　that　can　be　further　simplified　into　a　4,4-connected　pts　net　linked　from　planar　square　and　tetrahedra.　This　work　provides　fresh　insights　into　the　design　and　synthesis　of　frameworks　constructed　from　coordinatively,　covalently,　and　noncovalently　linked　building　units.