It　was　the　aim　of　this　work　to　investigate　equilibrium　and　thermodynamic　aspects　for　static　adsorption　of　bovine　serum　albumin　(BSA)　as　model　protein　of　extracellular　polymer　substances　(EPS)　from　membrane　bioreactor　(MBR)　on　hydrophilic　polyvinylidene　fluoride　(PVDF)　microfiltration　membrane.　In　present　paper,　the　influences　of　temperature,　pH　and　ionic　strength　were　studied　and　eight　different　isotherm　models　were　used　to　fit　equilibrium　data　by　nonlinear　regression　method.　The　obtained　results　showed　that　the　best-fitted　adsorption　isotherm　models　were　in　the　order　of:　Langmuir　and　Freundlich　＞　BET　＞　Langmuir　approximate　to　Redlich-Peterson　approximate　to　Temkin　＞　Freundlich　＞　Fowler　and　Guggenheim　(Hill-De　Boer),　of　which,　Langmuir-Freundlich　isotherm　is　the　best　suitable.　Thermodynamic　investigation　indicated　that　this　process　was　not　spontaneous　and　endothermic　and　maybe　attributed　to　physicosorption,　and　the　distribution　of　BSA　adsorbed　on　PVDF　membrane　was　more　chaotic　than　that　in　the　aqueous　solution.　The　results　from　the　static　adsorption　of　BSA　on　PVDF　membrane　can　be　a　useful　tool　to　evaluate　the　behavior　of　membrane　biofouling　in　MBR　and　also　provide　basis　for　performance　comparison　among　different　membranes.　(C)　2012　Elsevier　B.V.　All　rights　reserved.