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作者:

Wang, Yifang (Wang, Yifang.) | Nie, Jing (Nie, Jing.) | Wang, Yiwu (Wang, Yiwu.) | Zhang, Luo (Zhang, Luo.) | Lu, Kefeng (Lu, Kefeng.) | Xing, Guichun (Xing, Guichun.) | Xie, Ping (Xie, Ping.) | He, Fuchu (He, Fuchu.) | Zhang, Lingqiang (Zhang, Lingqiang.)

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Scopus SCIE

摘要:

CKIP-1 is an activator of the Smurf1 ubiquitin ligase acting to promote the ubiquitylation of Smad5 and MEKK2. The mechanisms involved in the recognition and degradation of these substrates by the proteasome remain unclear. Here, we show that CKIP-1, through its leucine zipper, interacts directly with the Rpt6 ATPase of the 19S regulatory particle of the proteasome. CKIP-1 mediates the Smurf1-Rpt6 interaction and delivers the ubiquitylated substrates to the proteasome. Depletion of CKIP-1 reduces the degradation of Smurf1 and its substrates by Rpt6. These findings reveal an unexpected adaptor role of CKIP-1 in coupling the ubiquitin ligase and the proteasome.

关键词:

Rpt6 ubiquitin ligase proteasome Smurf1 adaptor protein

作者机构:

  • [ 1 ] [Wang, Yifang]Beijing Inst Radiat Med, Beijing Proteome Res Ctr, Dept Genom & Prote, State Key Lab Prote, Beijing 100850, Peoples R China
  • [ 2 ] [Wang, Yiwu]Beijing Inst Radiat Med, Beijing Proteome Res Ctr, Dept Genom & Prote, State Key Lab Prote, Beijing 100850, Peoples R China
  • [ 3 ] [Zhang, Luo]Beijing Inst Radiat Med, Beijing Proteome Res Ctr, Dept Genom & Prote, State Key Lab Prote, Beijing 100850, Peoples R China
  • [ 4 ] [Lu, Kefeng]Beijing Inst Radiat Med, Beijing Proteome Res Ctr, Dept Genom & Prote, State Key Lab Prote, Beijing 100850, Peoples R China
  • [ 5 ] [Xing, Guichun]Beijing Inst Radiat Med, Beijing Proteome Res Ctr, Dept Genom & Prote, State Key Lab Prote, Beijing 100850, Peoples R China
  • [ 6 ] [Xie, Ping]Beijing Inst Radiat Med, Beijing Proteome Res Ctr, Dept Genom & Prote, State Key Lab Prote, Beijing 100850, Peoples R China
  • [ 7 ] [He, Fuchu]Beijing Inst Radiat Med, Beijing Proteome Res Ctr, Dept Genom & Prote, State Key Lab Prote, Beijing 100850, Peoples R China
  • [ 8 ] [Zhang, Lingqiang]Beijing Inst Radiat Med, Beijing Proteome Res Ctr, Dept Genom & Prote, State Key Lab Prote, Beijing 100850, Peoples R China
  • [ 9 ] [Wang, Yifang]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 10 ] [He, Fuchu]Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China
  • [ 11 ] [Wang, Yifang]Natl Engn Res Ctr Prot Drugs, Beijing 10206, Peoples R China
  • [ 12 ] [Wang, Yiwu]Natl Engn Res Ctr Prot Drugs, Beijing 10206, Peoples R China
  • [ 13 ] [Zhang, Luo]Natl Engn Res Ctr Prot Drugs, Beijing 10206, Peoples R China
  • [ 14 ] [Lu, Kefeng]Natl Engn Res Ctr Prot Drugs, Beijing 10206, Peoples R China
  • [ 15 ] [Xing, Guichun]Natl Engn Res Ctr Prot Drugs, Beijing 10206, Peoples R China
  • [ 16 ] [Xie, Ping]Natl Engn Res Ctr Prot Drugs, Beijing 10206, Peoples R China
  • [ 17 ] [He, Fuchu]Natl Engn Res Ctr Prot Drugs, Beijing 10206, Peoples R China
  • [ 18 ] [Zhang, Lingqiang]Natl Engn Res Ctr Prot Drugs, Beijing 10206, Peoples R China
  • [ 19 ] [Nie, Jing]Peoples Liberat Army Gen Hosp, Dept Mol Biol, Beijing 100853, Peoples R China
  • [ 20 ] [Zhang, Lingqiang]Dalian Med Univ, Inst Canc Stem Cell, Dalian 116044, Liaoning Provin, Peoples R China

通讯作者信息:

  • [He, Fuchu]Beijing Inst Radiat Med, Beijing Proteome Res Ctr, Dept Genom & Prote, State Key Lab Prote, 27 Taiping Rd, Beijing 100850, Peoples R China

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来源 :

EMBO REPORTS

ISSN: 1469-221X

年份: 2012

期: 11

卷: 13

页码: 1004-1011

7 . 7 0 0

JCR@2022

ESI学科: MOLECULAR BIOLOGY & GENETICS;

JCR分区:1

中科院分区:2

被引次数:

WoS核心集被引频次: 11

SCOPUS被引频次: 11

ESI高被引论文在榜: 0 展开所有

万方被引频次:

中文被引频次:

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