The　bimodal　mesoporous　silicas　with　short　random　mesoporous　channels　and　MCM-41　with　long　ordered　mesopores　were　synthesised　and　modified　with　3-(2-aminoethylamino)　propyltrimethoxysilane　as　ibuprofen　carriers　to　study　the　influence　of　mesoporous　structure　on　drug　delivery　property.　For　further　comparing　the　different　mesoporous　channels,　modified　SBA-15　with　relative　large　and　long　ordered　mesopores　was　also　synthesized　as　drug　carriers.　The　resultant　samples　were　characterized　with　X-ray　diffraction,　scanning　electron　microscopy,　transmission　electron　microscopy,　Fourier　transform　infrared　spectra,　N-2　adsorption-desorption　isotherms,　thermogravimetric　analyses,　solid-state　Si-29　NMR　spectra,　elemental　analysis,　and　UV-vis　spectra.　Meanwhile,　the　Korsmeyer-Peppas　equation　f(t)　=　kt(n)　was　employed　to　analyze　the　drug　release　profile　and　three　release　mediums　including　simulated　fluid　solution,　distilled　water　and　simulated　gastric　fluid　were　used.　The　results　indicated　that　the　modified　BMMs　with　the　bimodal　mesopores　leaded　to　the　most　drug　loading　amount　of　25.0　mg/0.1　g,　while　the　MCM-41　with　the　long　and　one-dimensional　mesopores　had　the　least　loading　amount　around　20.3　mg/0.1　g.　Meanwhile,　the　easier　diffusion　behavior　of　drug　molecules　in　the　bimodal　mesopore　channels　of　BMMs　resulted　in　relatively　faster　drug　release　properties　in　comparison　with　MCM-41,　while　the　release　time　maintained　in　SBF　for　about　12　h　(release　percent　was　about　90　wt%)　and　corresponding　release　constant　k　obtained　from　Korsmeyer-Peppas　equation　was　around　4.10.　(C)　2012　Elsevier　B.V.　All　rights　reserved.