HIV-1　integrase　(IN)　is　a　crucial　enzyme　in　the　life　cycle　of　HIV-1　and　also　a　validated　target　for　developing　anti-HIV　inhibitors.　Recent　progress　in　drug　design　has　significantly　accelerated　the　development　of　anti-AIDS　IN　inhibitors.　A　large　amount　of　novel　inhibitors　that　interact　specifically　with　IN　were　developed　along　with　the　expanding　and　application　of　methods　to　drug　design.　This　article　reviewed　the　anti-HIV　IN　inhibitors　discovered　by　the　rational　drug　design　approaches　in　the　recent　5-year.