Both　sulfonopeptides　and　phosphonopeptides　are　important　analogs　of　naturally　occurring　peptides　and　have　been　widely　used　as　enzyme　inhibitors　and　haptens　for　producing　catalytic　antibodies　due　to　their　tetrahedrally　structural　features.　A　series　of　hybrid　sulfonophosphinodipeptides　composing　of　taurines　and　1-aminoalkylphosphinic　acids　were　first　and　conveniently　synthesized　in　satisfactory　to　good　yields　via　a　Mannich-type　reaction　of　N-benzyloxycarbonylaminoalkanesulfonamides,　aldehydes,　and　aryldichlorophosphines,　and　subsequent　hydrolysis.　The　current　method　provides　an　efficient　and　direct　synthesis　of　hybrid　sulfonophosphinodipeptides.