To　investigate　the　effect　of　preoperative　induction　chemotherapy　on　treatment　of　recurrent　liposarcoma.　21　patients　with　recurrent　liposarcoma　received　the　treatment　of　preoperative　intra-arterial　chemotherapy　and　surgical　resection.　Intra-arterial　chemotherapy　was　given　by　subcutaneous　implantable　drug　delivery　system　with　infusion　of　cisplatin　and　doxorubicin　followed　by　caffeine.　After　treatment,　patients　were　followed　up　for　39　months.　The　liposarcoma　changes　in　CT　imaging　were　observed　in　18　cases　and　there　were　15　cases　with　medium　or　severe　pathological　changes　caused　by　chemotherapy.　At　the　end　of　the　postoperative　follow-up　of　39　months,　liposarcoma　reoccurred　locally　in　2　cases;　pulmonary　metastasis　occurred　in　1　case　and　death　in　3　cases.　Preoperative　intra-arterial　chemotherapy　is　effective　for　highly　malignant　tumors　such　as　recurrent　liposarcoma　and　the　judgment　of　prognosis　is　based　on　the　postoperative　pathological　changes　of　such　tumor.