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Author:

Wang, Lei (Wang, Lei.) | Liu, Shenquan (Liu, Shenquan.) | Zhang, Jing (Zhang, Jing.) | Zeng, Yanjun (Zeng, Yanjun.)

Indexed by:

Scopus SCIE

Abstract:

Neuronal membrane capacitance C (m) is one of the prominent factors in action potential initiation and propagation and then influences the firing patterns of neurons. Exploring the roles that C (m) plays in different firing patterns can facilitate the understanding of how different factors might influence neuronal firing behaviors. However, the impacts of variations in C (m) on neuronal firing patterns have been only partly explored until now. In this study, the influence of C (m) on burst firing behaviors of a two-compartment pyramidal neuron (including somatic compartment and dendritic compartment) was investigated by means of computer simulation, the value of C (m) in each compartment was denoted as C (m,s) and C (m,d), respectively. Two cases were considered, in the first case, we let C (m,s) = C (m,d), and then changed them simultaneously. While in the second case, we assumed C (m,s) not equal C (m,d), and then changed them, respectively. From the simulation results obtained from these two cases, it was found that the variation of C (m) in the somatic compartment and the dendritic compartment show much difference, simulated results obtained from the variation of C (m,d) have much more similarities than that of C (m,s) when comparing with the results obtained in the first case under which C (m,s) = C (m,d). These different effects of C (m,s) and C (m,d) on neuronal firing behaviors may result from the different topology and functional roles of soma and dendrites. Numerical results demonstrated in this paper may give us some inspiration in understanding the possible roles of C (m) in burst firing patterns, especially their transitions in compartmental neurons.

Keyword:

Two-compartment pyramidal neuron ISI Periodic bifurcation Burst firing Membrane capacitance

Author Community:

  • [ 1 ] [Zhang, Jing]Beijing Univ Technol, Ctr Biomed Engn, Beijing 100022, Peoples R China
  • [ 2 ] [Zeng, Yanjun]Beijing Univ Technol, Ctr Biomed Engn, Beijing 100022, Peoples R China
  • [ 3 ] [Wang, Lei]S China Univ Technol, Dept Math, Guangzhou 510640, Guangdong, Peoples R China
  • [ 4 ] [Liu, Shenquan]S China Univ Technol, Dept Math, Guangzhou 510640, Guangdong, Peoples R China

Reprint Author's Address:

  • [Zeng, Yanjun]Beijing Univ Technol, Ctr Biomed Engn, Beijing 100022, Peoples R China

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Source :

NEUROLOGICAL SCIENCES

ISSN: 1590-1874

Year: 2012

Issue: 3

Volume: 33

Page: 595-604

3 . 3 0 0

JCR@2022

ESI Discipline: NEUROSCIENCE & BEHAVIOR;

JCR Journal Grade:3

CAS Journal Grade:4

Cited Count:

WoS CC Cited Count: 10

SCOPUS Cited Count: 12

ESI Highly Cited Papers on the List: 0 Unfold All

WanFang Cited Count:

Chinese Cited Count:

30 Days PV: 0

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