Nano-hydroxyapatite　(nano-HA),　with　similar　components　of　human　bone　tissues　and　good　biomechanical　properties,　is　considered　as　the　most　promising　bioactive　material.　Its　application,　however,　is　still　limited　because　of　its　lack　of　bone　induction　effect.　To　assess　the　ability　of　polypro　nano-HA/fibrin　glue/recombination　human　osteogenic　protein-1　(nano-HA/FG/rhOP-1)　for　bone　defect　reconstruction.　After　the　unilateral　radius　bone　defect　was　established　at　the　45　New　Zealand　white　rabbits,　they　were　randomly　divided　into　the　nano-HA/FG/rhOP-1　(Group　A),　nano-HA/FG　(Group　B)　and　control　groups　(Group　C;　without　repair),　each　with　15　rabbits.　The　ability　of　bone　defect　repair　was　evaluated　by　gross　observation,　X-ray　radiography,　scanning　electronic　microscope,　radionuclide　bone　imaging　and　biomechanical　analysis　at　4,　8　and　12　weeks　after　repair.　The　radio　graphically　score,　bone　formation,　radionuclide　intake　ratio　and　biomechanical　strength　were　higher　in　the　nano-HA/FG/rhOP-1　group　than　the　nano-HA/FG　and　control　groups　at　4,　8　and　12　weeks　(P　＜　0.05).　There　were　no　bone　connection　at　the　defect　site　and　the　bone　defect　was　reconstructed　in　the　control　group.　It　is　indicated　that　the　nano-HA/FG/rhOP-1　artificial　bone　has　good　osteoconductibility　and　is　a　promising　material　for　repair　of　bone　defect.