Three　kinds　of　bimodal　mesopores　silica-based　nanomaterials　(BMMs)　with　different　accumulated　pores　structure　were　synthesized　by　tuning　the　stirring　rate　in　the　preparation　process　and　then　functionalized　with　silane　coupling　agent　3-(2-aminoethylamino)　propyltrimethoxysilane　(NN-TES).　The　modified　BMMs　were　used　as　ibuprofen　carriers　and　their　delivery　property　were　studied　with　Korsmeyer-Peppas　model.　With　the　help　of　XRD,　TEM,　N-2　adsorption　and　desorption　isotherms　and　elemental　analysis,　it　indicated　that　the　hydrolysis　and　condensation　polymerization　rate　of　TEOS　would　be　influenced　by　changing　the　stirring　rate,　which　resulted　in　the　formation　of　three　kinds　of　BMMs　with　different　small　pores　order　and　large　accumulated　pores　structure.　When　applying　NN-TES　modified　BMMs　as　ibuprofen　carriers,　the　ibuprofen　loading　amount　in　three　different　kinds　of　BMMs　were　almost　the　same,　while　the　release　rate　had　great　difference　from　each　other.　These　results　demonstrate　that　the　drug　loading　capacity　was　affected　by　the　small　pores　of　BMMs,　while　the　large　pores　of　BMMs　would　influence　the　drug　diffusion　behaviours　in　the　mesoporous　channel,　leading　to　the　increase　of　release　rate　with　the　increment　of　the　large　pore　size.